Marie taught school and by making friends with the roughnecks, she won their cooperation. She married a farmer, Jesse Romine, near Harveysburg. Marie always wanted to be a doctor but never had the opportunity. Unable to have children, they adopted one of her sister Rebecca’s girls, hoping that she would be willing to go to medical school. Unfortunately, the girl was not interested in becoming a doctor.
Marie’s husband finally persuaded Marie to fulfill her own dream. She graduated from medical school in Cincinnati and was the first woman doctor licensed to practice medicine in Ohio. Her practice was in Harveysburg and the surrounding area. The family thought of Dr. Mary L. Cook as Dr. Marie Romine’s “convert” to medicine. Mary worked in Dr. Marie's office while she attended high school in Harveysburg.